Detalhe da pesquisa
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26046436
2.
Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier.
PLoS Pathog
; 16(5): e1008204, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32357162
3.
Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica-Induced Sterile Inflammation.
J Immunol
; 200(10): 3556-3567, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29610142
4.
Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State.
Antimicrob Agents Chemother
; 60(8): 4552-62, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27185801
5.
Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.
PLoS Pathog
; 10(6): e1004213, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24967809
6.
The murine model for Hantaan virus-induced lethal disease shows two distinct paths in viral evolutionary trajectory with and without ribavirin treatment.
J Virol
; 87(20): 10997-1007, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-23903835
7.
A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus.
Virol J
; 10: 19, 2013 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-23302182
8.
Identification of potent small molecule inhibitors of SARS-CoV-2 entry.
SLAS Discov
; 27(1): 8-19, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35058179
9.
HTS-driven discovery of new chemotypes with West Nile Virus inhibitory activity.
Molecules
; 15(3): 1690-704, 2010 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-20336008
10.
Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production.
Antiviral Res
; 174: 104674, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31816348
11.
Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses.
Antiviral Res
; 167: 25-34, 2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30970271
12.
High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2).
J Biomol Screen
; 13(9): 879-87, 2008 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-18812571
13.
Synthesis of 1-beta-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus.
Antiviral Res
; 79(1): 19-27, 2008 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-18394724
14.
Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay.
Antiviral Res
; 138: 47-56, 2017 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27919709
15.
Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus.
Sci Rep
; 7(1): 16652, 2017 11 30.
Artigo
Inglês
| MEDLINE | ID: mdl-29192272
16.
Phenotypic differences in virulence and immune response in closely related clinical isolates of influenza A 2009 H1N1 pandemic viruses in mice.
PLoS One
; 8(2): e56602, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23441208
17.
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.
J Med Chem
; 55(20): 8582-7, 2012 Oct 25.
Artigo
Inglês
| MEDLINE | ID: mdl-23043370
18.
Synthesis and anti-Hantaan virus activity of N(1)-3-fluorophenyl-inosine.
Antiviral Res
; 83(1): 80-5, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19501259
19.
Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase.
Antimicrob Agents Chemother
; 51(1): 84-8, 2007 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-17060520
20.
Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus.
J Virol
; 81(21): 11722-9, 2007 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17699579